Associate Professor
School of Applied Physiology |
 |
Education
- Ph.D., Bioengineering, University of California, San Diego, 1997
- B.S.E, Bioengineering, University of Pennsylvania, 1991
Research Interests
Dr. Burkholder's research explores the coordination of skeletal muscle structure and function. This work has two thrusts: understanding the mechanism by which mechanical signals alter muscle structure and understanding the functional demands on muscle. His principle work is focused on the mechanism by which mechanical perturbation of the cell membrane may initiate the biochemical cascade that causes stretch-induced muscle growth and understanding the regulation and interaction of the downstream signaling cascades. Additional work is aimed at understanding how spinal reflex mechanisms interact with muscular motors and skeletal kinematics to control posture.
More detailed information can be found on his lab website.
Course outlines
- APPH 4600/6600 Muscle Physiology
- APPH 6211 Systems Physiology I: Cell
- BMED 8813 Hybrid Neural Microsystems
Past students
- Bellott, Anne Claire The Role of Caveolae in the Loss of ERK2 Activation in Stretched Skeletal Myotubes, MSBE 2004
- Brathwaite, Ricky C. Mechanical Stretch and Electrical Stimulation in Mouse Skeletal Muscle In Vivo: Initiation of Hypertrophic Signaling, MSBE 2004
- Bunderson, Nathan E. The Role of Heterogenic Spinal Reflexes in Coordinating and Stabilizing a Model Feline Hindlimb, Ph.D. (Bioengineering) 2008
Select Publications
- Bunderson NE; Ting LH; McKay JL; Burkholder TJ. Directional constraint of endpoint force emerges from hindlimb anatomy Journal of Experimental Biology 2010 213:2131-2141. PubMed | Online
- Rahnert JA; Sokoloff AJ; Burkholder TJ. Sarcomeric myosin expression in tongue body of human, macaque and rat. Cells Tissues Organs 2010 191:431-442. PubMed | Online
- Burkholder TJ. Stretch-induced ERK2 phosphorylation requires PLA2 activity in skeletal myotubes Biochemical and Biophysical Research Communications 2009 386:60-64. PubMed | Online
- Frey, JW; Farley EE; O'Neil TK; Burkholder TJ; Hornberger TA. Evidence that mechanosensors with distinct biomechanical properties allow for specificity in mechanotransduction Biophysical Journal (2009) 97:347-356. PubMed | Online
- Bunderson, NE; Burkholder, TJ; Ting, LH. Reduction of neuromuscular redundancy for postural force generation using an intrinsic stability criterion. Journal of Biomechanics 2008 41:1537-1544. PubMed | Online
- van Antwerp, KW; Burkholder, TJ; Ting, LH. Inter-joint coupling effects on muscle contributions to endpoint force and acceleration in a musculoskeletal model of the cat hindlimb Journal of Biomechanics 2007 40:3570-3579 PubMed | Online
- Sokoloff, AJ; Li, H; Burkholder, TJ. Limited expression of slow tonic myosin heavy chain in human cranial muscles. Muscle and Nerve 2007 Aug 36:183-189 PubMed | Online
- Bunderson, NE; Ting, LH; Burkholder, TJ. Asymmetric interjoint feedback contributes to postural control of redundant multi-link systems. Journal of Neural Engineering (2007) 4:234-245
- Sokoloff, AJ; Yang, B; Li, H; Burkholder, TJ. Immunohistochemical characterization of slow and fast myosin heavy chain composition of muscle fibres in the stylolossus muscle of the human and macaque (Macaca rhesus). Archives of Oral Biology (2007) 52:533-543. PubMed | Online
- Burkholder, TJ. Mechanotransduction in skeletal muscle. Frontiers in Bioscience (2007) 12:174-191. Online
- McKay, JL; Burkholder, TJ; Ting, LN. Biomechanical capabilities influence postural control strategies in the cat hindlimb. Journal of Biomechanics 2006 40:2254-2260 Pubmed | Preprint
- Otis, JS; Burkholder, TJ; Pavlath, GK. Stretch-induced myoblast proliferation is dependent on the COX2 pathway. Experimental Cell Research 2005 Nov 1;310(2):417-25 PubMed | Online
- Bellott, AC; Patel, KC; Burkholder, TJ. Reduction of caveolin-3 expression does not inhibit stretch induced phosphorylation of ERK-2 in skeletal muscle myotubes. Journal of Applied Physiology (2005) 98:1554-1561. PubMed | Online
- Hornberger, TA; Armstrong, DD; Koh, TJ; Burkholder, TJ and Esser, KA. Intracellular Signaling Specificity in Response to Uniaxial vs. Multiaxial Stretch: Implications for Mechanotransduction American Jounal of Physiology: Cell Physiology (2005) 288:C185-194. PubMed | Online
- Burkholder, TJ. Age does not influence muscle fiber length adaptation to increased excursion. Journal of Applied Physiology (2001), 91:2466-70. [PubMed] | [Text]
- Burkholder, TJ and Lieber, RL. Sarcomere length operating range of vertebrate muscles during movement. Journal of Experimental Biology (2001) 204:1529-1536. [PubMed] | [pdf]
- Burkholder, TJ and Lieber, RL. Sarcomere number adaptation following retinaculum release in adult mice. Journal of Experimental Biology (1998) 201(3):309-316. [PubMed] | [pdf]
- Loren, GJ; Shoemaker, SD; Burkholder, TJ; Jacobson, MD; Fridén, J; Lieber, RL. Human wrist motors: Biomechanical design and application to tendon transfers. Journal of Biomechanics (1996) 29(3):331-342. Online
- Burkholder, TJ; Fingado, B; Baron, S; Lieber, RL. Relationship between muscle fiber types and sizes and muscle architectural properties in the mouse hindlimb. Journal of Morphology (1994) 221:177-190. [PubMed]