School of Applied Physiology
Georgia Institute of Technology
Fall 2010
Course No. & Title: APPH 8803, Methods in Human Neuroimaging
| Credit Hours: | 3 credit hours |
| Lecture time/day: | Thursday, 2.:00 - 5:00 PM |
| Locations of Class: | Main Location: Weber conference room 121 |
| Course Instructor: | Dr. Lewis Wheaton |
| Office Hours: | by appointment |
| Office Location: | 104 Weber SST |
| Office Phone: | 404-895-2339 |
| E-mail: | lewis.wheaton@ap.gatech.edu |
Guest Lecturers:
Required Text:
General Course Description:
The purpose of this course is to introduce various methods of functional neuroimaging in humans. At the end of the course, it is expected that students will be conversant in imaging modalities, techniques, and collection/analysis methods related to invasive and non-invasive methods of understanding human brain function.
The Georgia Tech Honor Code will be strictly enforced.
Course Grading
| Article Presentation(s) | 30% |
| Presentation of research project | 20% |
| Written proposal of research idea | 20% |
| Exams (final) | 30% |
| Total | 100% |
Article Presentations:
Article presentations will be based on articles selected by the instructor to present and discuss in class. Students may use PowerPoint or other presentation strategies. It is expected that students lead the discussion with a focus on describing the analysis method used in the paper. At the instructors’ determination, these will be either individual or group presentation efforts.
Presentation of Research Project
Students are expected to select one (or more) methods of human brain imaging and develop a study using the selected method. Presentations will be done using PowerPoint and will be 10 minutes in duration. At the instructors’ determination, these will be either individual or group presentation efforts.
Written Proposal of Research Idea
Based on the abovementioned presentation, students will write a short (2 page, single space, 1” margin, no figures, Arial 10) “Letter of Intent” specifically detailing the purpose, design, hypotheses, expectation, and relevance of the proposed study. More details will follow.
Final Exam:
A final exam will be performed. Details will be given on the first day of class.
Tentative Semester Schedule (variable at Dr. Wheaton’s discretion)
| Week | Topics | Readings | Other Details |
| 1- 8/26 | Introductions, course overview, introduction to brain function, anatomy and cartography | Ch 1, 2 | |
| 2 – 9/2 | Brain function, optical imaging, blood flow, and electrical acquisition in animals | Ch 3-5, 7 | Journal article assignments |
| 3 – 9/9 | -EEG, MEG | Ch 8-10 | Guest lecture – Dr. Chris Mizelle |
| 4 – 9/16 | -EEG and MEG (continued) | TBD | DISCUSS RESEARCH PROJECT IDEAS |
| 5 – 9/23 | -TMS, NIRS | Ch 6, 11 | Guest Lecture – Dr. Andrew Butler |
| 6 – 9/30 | -TMS, NIRS (continued) | TBD | ARTICLE PRESENTATION WEEK |
| 7 – 10/7 | -fMRI | Ch 12-13, 16 | Guest Lecture – Dr. Chris Rorden at CABI |
| 8 – 10/14 | -DTI | Ch 15 | ARTICLE PRESENTATION WEEK |
| 9 – 10/21 | -PET, SPECT | Ch 18, 19 | DISCUSS RESEARCH PROJECT IDEAS |
| 10 – 10/28 | ARTICLE PRESENTATION WEEK | TBD | |
| 11 – 11/4 | Presentation day | None | Letter of Intent DUE |
| 12 – 11/11 | Postmortem | Ch 21 | |
| 13 – 11/18 | Combinatorial methods | Ch 25 | |
| 14 – 11/28 | Thanksgiving BREAK | ||
| 15 – 12/2 | Paradigms, statistics | Ch 22-23 | |
| 16 – 12/7 | “Emerging Concepts” - TBD | Ch 29-31 |
Articles to Choose From (Other articles may be selected, if approved in advance)
Bai O, Vorbach S, Hallett M, Floeter MK (2006) Movement-related cortical potentials in primary lateral sclerosis. Ann Neurol 59: 682-690.
Del Percio C, Babiloni C, Bertollo M, Marzano N, Iacoboni M, Infarinato F, Lizio R, Stocchi M, Robazza C, Cibelli G, Comani S, Eusebi F (2009) Visuo-attentional and sensorimotor alpha rhythms are related to visuo-motor performance in athletes. Hum Brain Mapp 30: 3527-3540.
Aziz-Zadeh L, Koski L, Zaidel E, Mazziotta J, Iacoboni M (2006) Lateralization of the human mirror neuron system. J Neurosci 26: 2964-2970.
Goldstone AP, de Hernandez CG, Beaver JD, Muhammed K, Croese C, Bell G, Durighel G, Hughes E, Waldman AD, Frost G, Bell JD (2009) Fasting biases brain reward systems towards high-calorie foods. Eur J Neurosci 30: 1625-1635.
Fridman EA, Hanakawa T, Chung M, Hummel F, Leiguarda RC, Cohen LG (2004) Reorganization of the human ipsilesional premotor cortex after stroke. Brain 127: 747-758.
Kim DE, Shin MJ, Lee KM, Chu K, Woo SH, Kim YR, Song EC, Lee JW, Park SH, Roh JK (2004) Musical training-induced functional reorganization of the adult brain: Functional magnetic resonance imaging and transcranial magnetic stimulation study on amateur string players. Hum Brain Mapp 23: 188.
Klein D, Watkins KE, Zatorre RJ, Milner B (2006) Word and nonword repetition in bilingual subjects: a PET study. Hum Brain Mapp 27: 153-161.
Grafton ST, Hazeltine E, Ivry RB (2002) Motor sequence learning with the nondominant left hand. A PET functional imaging study. Exp Brain Res 146: 369-378.
Bhadelia RA, Price LL, Tedesco KL, Scott T, Qiu WQ, Patz S, Folstein M, Rosenberg I, Caplan LR, Bergethon P (2009) Diffusion Tensor Imaging, White Matter Lesions, the Corpus Callosum, and Gait in the Elderly. Stroke.
Dubois J, Dehaene-Lambertz G, Soares C, Cointepas Y, Le Bihan D, Hertz-Pannier L (2008) Microstructural correlates of infant functional development: example of the visual pathways. J Neurosci 28: 1943-1948.
Waldert S, Preissl H, Demandt E, Braun C, Birbaumer N, Aertsen A, Mehring C (2008) Hand movement direction decoded from MEG and EEG. J Neurosci 28: 1000-1008.
Kuriki S, Kanda S, Hirata Y (2006) Effects of musical experience on different components of MEG responses elicited by sequential piano-tones and chords. J Neurosci 26: 4046-4053.