Thomas J. Burkholder, Ph.D.
Associate Professor
School of Applied Physiology
Email: thomas.burkholder@ap.gatech.edu
Phone: (404) 894-1029
Office: Weber SST 100B
Education
Ph.D., Bioengineering, University of California, San Diego, 1997B.S.E, Bioengineering, University of Pennsylvania, 1991
Research Interests
Dr. Burkholder's research explores the coordination of skeletal muscle structure and function. This work has two thrusts: understanding the mechanism by which mechanical signals alter muscle structure and understanding the functional demands on muscle. His principle work is focused on the mechanism by which mechanical perturbation of the cell membrane may initiate the biochemical cascade that causes stretch-induced muscle growth and understanding the regulation and interaction of the downstream signaling cascades. Additional work is aimed at understanding how spinal reflex mechanisms interact with muscular motors and skeletal kinematics to control posture.
More detailed information can be found on his lab website.
Course outlines
APPH 4600/6600 Muscle PhysiologyAPPH 6211 Systems Physiology I: Cell
BMED 8813 Hybrid Neural Microsystems
Past students
Bellott, Anne Claire The Role of Caveolae in the Loss of ERK2 Activation in Stretched Skeletal Myotubes, MSBE 2004Brathwaite, Ricky C. Mechanical Stretch and Electrical Stimulation in Mouse Skeletal Muscle In Vivo: Initiation of Hypertrophic Signaling, MSBE 2004
Bunderson, Nathan E. The Role of Heterogenic Spinal Reflexes in Coordinating and Stabilizing a Model Feline Hindlimb, Ph.D. (Bioengineering) 2008
Selected Publications
Bunderson, NE; Burkholder, TJ; Ting, LH. Reduction of neuromuscular redundancy for postural force generation using an intrinsic stability criterion. Journal of Biomechanics 2008 41:1537-1544. PubMed | Onlinevan Antwerp, KW; Burkholder, TJ; Ting, LH. Inter-joint coupling effects on muscle contributions to endpoint force and acceleration in a musculoskeletal model of the cat hindlimb Journal of Biomechanics 2007 40:3570-3579 PubMed | Online
Sokoloff, AJ; Li, H; Burkholder, TJ. Limited expression of slow tonic myosin heavy chain in human cranial muscles. Muscle and Nerve 2007 Aug 36:183-189 PubMed | Online
Bunderson, NE; Ting, LH; Burkholder, TJ. Asymmetric interjoint feedback contributes to postural control of redundant multi-link systems. Journal of Neural Engineering (2007) 4:234-245
Sokoloff, AJ; Yang, B; Li, H; Burkholder, TJ. Immunohistochemical characterization of slow and fast myosin heavy chain composition of muscle fibres in the stylolossus muscle of the human and macaque (Macaca rhesus). Archives of Oral Biology (2007) 52:533-543. PubMed | Online
Burkholder, TJ. Mechanotransduction in skeletal muscle. Frontiers in Bioscience (2007) 12:174-191. Online
McKay, JL; Burkholder, TJ; Ting, LN. Biomechanical capabilities influence postural control strategies in the cat hindlimb. Journal of Biomechanics 2006 40:2254-2260 Pubmed | Preprint
Otis, JS; Burkholder, TJ; Pavlath, GK. Stretch-induced myoblast proliferation is dependent on the COX2 pathway. Experimental Cell Research 2005 Nov 1;310(2):417-25 PubMed | Online
Bellott, AC; Patel, KC; Burkholder, TJ. Reduction of caveolin-3 expression does not inhibit stretch induced phosphorylation of ERK-2 in skeletal muscle myotubes. Journal of Applied Physiology (2005) 98:1554-1561. PubMed | Online
Hornberger, TA; Armstrong, DD; Koh, TJ; Burkholder, TJ and Esser, KA. Intracellular Signaling Specificity in Response to Uniaxial vs. Multiaxial Stretch: Implications for Mechanotransduction American Jounal of Physiology: Cell Physiology (2005) 288:C185-194. PubMed | Online
Burkholder, TJ. Age does not influence muscle fiber length adaptation to increased excursion. Journal of Applied Physiology (2001), 91:2466-70. [PubMed] | [Text]
Burkholder, TJ and Lieber, RL. Sarcomere length operating range of vertebrate muscles during movement. Journal of Experimental Biology (2001) 204:1529-1536. [PubMed] | [pdf]
Burkholder, TJ and Lieber, RL. Sarcomere number adaptation following retinaculum release in adult mice. Journal of Experimental Biology (1998) 201(3):309-316. [PubMed] | [pdf]
Loren, GJ; Shoemaker, SD; Burkholder, TJ; Jacobson, MD; Fridén, J; Lieber, RL. Human wrist motors: Biomechanical design and application to tendon transfers. Journal of Biomechanics (1996) 29(3):331-342. Online
Burkholder, TJ; Fingado, B; Baron, S; Lieber, RL. Relationship between muscle fiber types and sizes and muscle architectural properties in the mouse hindlimb. Journal of Morphology (1994) 221:177-190. [PubMed]
Last updated:
Friday, 15-Aug-2008 15:59:02 EDT